Programme

XVIII FISV Congress

MILAN 21 – 23 September

21 Sept.
22 Sept.
23 Sept.
Posters

12.00 – 18.00

Registration

13.30 – 14.00

Welcome Coffee

14.00 – 14.30

Opening Session

Chiara TONELLI

,

FISV President

Monica DILUCA

,

Vice Rector for Research and Technology Transfer University of Milan

14.30 – 15.15

FISV Lecture

Elena CATTANEO

,

University of Milan and INGM Milano

Huntington: the journey from gene sequence to neuronal damage

15.15 – 16.00

FUV Lecture

Franco LOCATELLI

,

Children’s Hospital Rome – Catholic University of the Sacred Heart Rome

CAR-T cells: from consolidated indications to the future applications in different diseases

16.00 – 18.00

SYMPOSIUM 1: Chronobiology: biological rhythms and their effect on living organisms

Chairs: Fiorella LO SCHIAVO, University of Padua
Rodolfo COSTA, University of Padua

Mariano PERALES

,

Polytechnic University of Madrid

Molecular mechanisms linking the circadian clock to tree seasonality

Paolo Maria TRIOZZI

,

Sant’Anna School of Advanced Studies

Oxygen: a missing input for the plant circadian clock?

Gian Michele RATTO

,

CNR, Italy

Intracellular chloride as a signalling hub linking the autonomous circadian clock with neuronal excitability

Nazareno CAPITANIO

,

University of Foggia

The Rhythm of Life: Intertwining Mitochondrial Metabolism and Circadian Clock-Genes in Health and Disease

18.00 – 19.00

Apericena

19.00 – 21.00

MINI-SYMPOSIA

MS1
MS2
MS3

MS1: Enviromental, evolutionary and developmental biology

Chairs: Andrea SCHUBERT, University of Turin
Anca MACOVEI, University of Pavia

Alessia AMETRANO

,

IBBC-CNR Naples

Simulated marine heatwaves reveal epigenetic regulation of the polymeric immunoglobulin receptor gene in Antarctic teleosts

Emanuele BOSI

,

University of Genoa

The resistome of European coastal environments revealed by high-resolution targeted metagenomics in oysters

Valerio FOSCHI

,

Roma Tre University

Modulation of thermospermine metabolism alters xylem architecture and drought resilience in Solanum lycopersicum plants

Flavia GRECO

,

University of Turin

Space worms: adaptation to microgravity and low magnetic field strength

Benedetta PIZZICONI

,

Campus Bio-Medico, University of Rome

Polystyrene nanoplastics uptake and genotype-dependent responses in durum wheat: from hydroponic to soil-grown systems

Ruihan SHEN

,

University of Turin

KAI2 receptors shape the response to nitrogen limitation and nitrogen use efficiency in tomato

Emanuele CAPRA

,

IBBA-CNR Lodi

PFNA exposure disrupts sperm function and reprograms the epigenome in male rats

MS2: Genetics, epigenetics and chromosome biology

Chairs: Giuseppe MERLA, University of Naples Federico II
Rossella TRICARICO, Univerisy of Pavia

Vittoria BRAMBILLA

,

University of Milan

Stem growth in rice is controlled by chromatin remodelling that promotes cell division at the intercalary meristem

Erika CASARI

,

University of Milano Bicocca

Activation of MRX endonuclease by the Sae2 C-terminus: functional and molecular insights

Martina GRECO

,

University of Trento

The intranuclear protein quality control pathway sequesters excess histone H3 variant Cse4 to prevent chromosomal instability in budding yeast

Anna PISCONE

,

University of Naples Federico II

XRCC1 deficiency promotes telomeric chromatin leakage, inflammatory signalling and senescence

Erica ROSSI

,

University Roma Tre

Telomerase reverse transcriptase as a modulator of mitochondrial DNA and mitophagy

Martina SANTULLI

,

University of Bologna

YEATS2 defines an E2F3-associated function of the ATAC core complex

Esi TACI

,

University of Milan

Exploring the link between cellular senescence and neurodegeneration using iDISCO on brain organoids

MS3: Genomics, proteomics and systems biology

Chairs: Candida VANNINI, University of Insubria Varese
Michela ZOTTINI, University of Padua

Alessia CANEVOTTI

,

University of Milan and CNR-IBIOM, Bari

An integrative evidence framework and interactive resource for annotating the human pre-miRNA repertoire

Guido DOMINGO

,

University of Insubria

Small peptides, big defense: chloroplast non-conventional peptides as novel regulators of thermal stress

Margherita FERRETTI

,

IRCCS National Cancer Institute Regina Elena Rome

Spontaneous miscarriage reveals CD47-SIRPa axis as a targetable immune checkpoint in endometrial cancer

Sophia LUCHE

,

University of Parma

Functional dynamics: metabolomic exploration of perennial wheat roots and their interacting microbial ecosystem

Marcello MANFREDI

,

University of Piemonte Orientale

Unraveling CSF protein complex networks in neurodegenerative diseases

Emanuela PEDRAZZINI

,

IBBA-CNR Milan

Lysine deserts in seed storage protein evolution

Davide PEZZINI

,

University of Pavia

Multi-omics approach to investigate the impact of seed coat pigmentation on Trifolium alexandrinum germination

19.00 – 21.00

POSTER PRESENTATION

P4
P5
P6

P4: Current trends in biotechnology

Chairs: Elisa CLAGNAN, University of Milan
Eleonora COMINELLI, CNR-IBBA, Milan

Giulia ANDERLUZZI

,

University of Milan

The effect of cationic polymer on the structure and pDNA transfection efficiency of lipopolyplexes

Giacomo BIRRO

,

University of Verona

Primed for stress: loss of Aucsia2 improves salt resilience in tomato

Michela BRUSCHI

,

University of Urbino Carlo Bo

Thiol-based compound hinders Pseudomonas aeruginosa pyocyanin redox cycling and dampens LPS-driven acute pulmonary inflammation

Simona COMPARATO

,

Istituto Nazionale Oncologico Candiolo

Exploring the expression pattern of LINE-1–derived chimeric transcript of MET (L1-MET) across different tumor types

Marco DAINELLI

,

University of Florence

Constitutive metabolic adjustments underlying thallium hyperaccumulation in Silene latifolia

Francesca GIANNESE

,

Human Technopole, Milan

The National Facility for Genomics of Human Technopole: Supporting Population Genomics Research and Technology Development in Italy

Giovanni MESSINA

,

Link Campus University, Rome

Setting up of an in vitro model to investigate the effects on cell metabolism induced by the photobiomodulation protocols used for plantar fasciopathy

Pietro ROVERSI

,

CNR-IBBA, Milan

Structural Basis of ERAD-L Commitment by an EDEM:PDI Checkpoint Complex

P5: Food and sustainable nutrition

Chairs: Stefania MASCI, University of Tuscia
Costanza CECCANTI, University of Pisa

Emma BERTOLE’

,

University of Milan

Set up method for assessing the amount and activity of wheat germ agglutinin lectin

Lorenzo BRUSETTI

,

Free University of Bolzano

Irrigation water quality drives antimicrobial resistance co-selection along the Adige Valley: preliminary findings from the AppleHealth project

Beatrice CHIAVACCI

,

University of Florence

Crops that inherit their stress memories: Cicer arietinum against salt stress

Elena DE AMICIS

,

University of L’Aquila

Microalgal bioactive compounds as natural elicitors for sustainable crop protection

Noemi DI VITA

,

University of Padua

Proof of concept for RNAi-based weed control in Solanum nigrum

Ridwan DIAGUNA

,

University of Pavia

Screening for heat stress tolerance in tomato: Impact on seed repair response

Alessandra MARINELLI

,

University of Milan

Anthocyanins as a possible strategy to protect against mycotoxin toxicity

Andrea PAGANO

,

University of Pavia

Synergies in seed quality research to enhance stress tolerance in model and orphan legumes

Maria Manuela RIGANO

,

University of Naples Federico II

Effect of combined shade and drought stress on a S. pennellii introgression line.

Marta TOCCACELI

,

University of Milan

Purple corn anthocyanins encapsulated in zein nanoparticles and their role against inflammatory bowel diseases in vitro

P6: Health and disease

Chairs: Franco FAORO, CREA-IT
Elena Bianca DONETTI, University of Milan

Giulia Luna BERGANTINO

,

University of Sannio

Selection of DNA aptamers targeting psoriasis-associated CARD14-mutant keratinocytes

Stefano BIRESSI

,

University of Trento

Reduced fibrosis after in vivo inhibition of complement C1 in animal models of Duchenne Muscular Dystrophy

Ludovica CAPONE

,

University of Sannio

Disruption of macrophage CBM complex signaling impairs adipocyte metabolic homeostasis in vitro.

Rosita DI PALMA

,

University of Naples Federico II

Targeting oxidative and ER stress to improve chemotherapy in lung cancer cell: the adjuvant role of olea europaea in lung cancer

Chiara DONATI

,

University of Pavia

Novel Riluzole-derivative VA942 affects voltage-gated sodium and potassium currents expressed in SH-SY5Y-derived neurons

Nicole MARCATI

,

University of Parma

Parallel Evolution of a GLP1R Residue in Mammals and Humans Reveals a Pharmacogenomic Determinant of GLP‑1 Receptor Agonist Response

Valentina MARGARITA

,

University of Sassari

Sex-based differences in prenatal innate immunity: divergent foetal responses to Mycoplasma hominis infection between males and females

Francesco ACQUATI

,

University of Insubria

Role of the human RNASET2 gene in the pathogenesis of Aicardi-Goutières syndrome.

Shirin NAVACCI

,

Sapienza University of Rome

AMBRA1 regulates Sonic Hedgehog signaling during cerebellar development and promotes SHH-medulloblastoma

Roberto OLEARI

,

University of Milan

Connecting craniofacial malformations with neural crest splicing defects by defining the role of nuclear cyclophilin NKTR

Zeudi PETRONE

,

University of Naples Federico II

Modelling diabetic corneal injury in ovo: a rapid platform for testing bioactive ophthalmic formulations

Gabriele SALES

,

University of Padua

Self-supervised learning reveals mutation-specific morphological signatures in Gaucher disease fibroblasts

Davide SARTINI

,

Marche Polytechnic University

Therapeutic potential of paraoxonase-2 enzyme in triple-negative breast cancer treatment

Chiara SCAPOLI

,

University of Ferrara

Recurrent pregnancy loss and smoking share CTNNA2 rs4852592 locus effects through independent pathways

08.30 – 10.30

PARALLEL SYMPOSIUM 2: Microbiome Modulation Across Systems: Human, Plant, and Soil Perspectives

Chairs: Francesco LORETO, University of Naples Federico II
Sabrina SARROCCO, University of Pisa

Vittoria CATARA

,

University of Catania

The microbiome as a systemic determinant of plant health.

Giuliano BONANOMI

,

University of Naples Federico II

Modulation of soil and rhizosphere microbiome to improve plant defence and ecosystem functions

Michele PERAZZOLLI

,

University of Trento

Plant-associated microbial communities contribute to abiotic stress resilience

Marco VENTURA

,

University of Parma

The role of bifidobacteria in shaping the human gut microbiotaThe role of bifidobacteria in shaping the human gut microbiota

08.30 – 10.20

PARALLEL SYMPOSIUM 3: Multiscale analysis of brain function and dysfunctions

Chairs: Anna FASSIO, University of Genoa
Tommaso FELLIN, Istituto Italiano di Tecnologia

Simona LODATO

,

Humanitas University

Early spontaneous activity shapes neuronal diversity and circuit assembly in the developing cerebral cortex

Nathalie ROCHEFORT

,

University of Edinburgh

Movie-trained transformer model reveals novel response properties to dynamic stimuli in mouse visual cortex

Alessandro GOZZI

,

University of Trento and Italian Institute of Technology

Multiscale Decoding of Functional Brain Maps

Marcello MASSIMINI

,

University of Milan

Cortical dynamics after brain injury: from neurons to networks

10.20 – 10.30

Claudia SCACCABAROZZI

,

Agilent Technologies

From Sample to Insight: Agilent Integrated Technologies for Modern Life Science Research

10.30 – 11.00

Coffee Break

11.00 – 12.50

PARALLEL SYMPOSIUM 4: RNA in mammals and plants

Chairs: Serena VAROTTO, University of Padua
Michela DENTI, University of Trento

Pablo MANAVELLA

,

University of Malaga

Tiny Transposons, Big Effects: How MITEs Organize Chromatin to Shape Gene Expression

Luca CAPRIOTTI

,

Marche Polytechnic University

RNAi: biotechnological strategies for sustainable plant protection

Germano CECERE

,

Institute Pasteur, Paris

Small RNAs in Epigenetic Inheritance: a lesson from worms

Fabiana QUAGLIA

,

University of Naples Federico II

Engineering RNA Delivery: From Nanoparticle Design to Translational Pipelines

12.50 – 13.00

Antonio CASINI

,

Anemocyte

Streamlining mRNA Manufacturing through AMCAP One-Pot Enzymatic Capping

11.00 – 13.00

PARALLEL SYMPOSIUM 5: Germline Pharmacogenetics: From Scientific Evidence to Clinical Implementation

Chairs: Chiara PESENTI, Anatomia patologica ASST BERGAMO OVEST, Treviglio
Monica MOZZO, University of Milan

Matteo FLORIS

,

University of Cagliari

Implementing Pharmacogenetics in Italy: National Initiatives and Strategic Priorities

Erika CECCHIN

,

Oncology Reference Center of Aviano

Clinical benefit and utility of pharmacogenetic testing in oncology: from targeted genotyping to the genetic passport

Laura FONTANA

,

University of Milan

Technical approaches for germline pharmacogenetic testing

Massimo GENNARELLI

,

University of Brescia

Pharmacogenetics in psychiatry

13.00 – 14.00

Lunch

14.00 – 16.00

SYMPOSIUM 6: Transposable and repetitive Elements in evolution and development

Chairs: Michele DE BORTOLI, University of Turin
Andrea LUCHETTI, University of Bologna

Didier TRONO

,

École Polytechnique Fédérale de Lausanne

The Endovirome, its epigenetic controllers and the species-specificity of human biology

Josep CASACUBERTA

,

CRAG Barcelona

LTR-retrotransposons, major drivers of genetic variability and key players in genome structure in plants

Maria Assunta BISCOTTI

,

Marche Polytechnic University

Let’s jump: Transposable Elements as drivers of genomic plasticity

Alessio BOATTINI

,

University of Bologna

Dating polymorphic transposable elements in human populations

16.00 – 17.00

FISV Prize

Chairs: Chiara TONELLI, FISV President
Chiara ZUCCATO, FISV Scientific Secretary

FISV Young Researchers Award – Winners:
ABBÀ Silvia, ALOISI Sara, GRENZI Matteo, ROSSINI Michela, TRIOZZI Paolo Maria, VENZIN Valentina

17.00 – 18.00

Apericena

19.00 – 21.00

MINI-SYMPOSIA

MS4
MS5
MS6

MS4: Current trends in biotechnology

Chairs: Roberto BASSI, Stazione Zoologica Anton Dohrn, Naples
Simone FERRARI, University of Rome La Sapienza

Germán Darío AHUMADA

,

Sant’Anna School of Advanced Studies, Pisa

Arabidopsis in vitro pipeline identified rice endophytic bacteria that promotes growth after submergence.

Nicolò ALBANESE

,

University of Sannio

Engineering and characterization of third-generation CAR-macrophages for solid tumor immunotherapy

Francesca AMODEO

,

University of Turin

Overcoming the silencing of doxycycline-inducible promoters in hiPSC-derived cardiomyocytes

Giulia BARBIERI

,

University of Pavia

Unlocking high-yield extracellular protease production in Bacillus subtilis by targeting the nutrient-responsive interplay between CodY and the stringent response

Roberto CAFERRI

,

University of Verona

Spectral re-design of LHCB proteins for engineering photosynthetic light use efficiency

Pasquale CREANZA

,

University of Urbino Carlo Bo

Development of a novel eco-friendly bioplastic from engineered phaseolin protein

Suleman Khan ZADRAN

,

University of Bologna

A theranostic M13 phage nanoplatform for systematic CD276 targeting in neuroblastoma

MS5: Food and sustainable nutrition

Chairs: Laura DE GARA, Campus Bio-Medico University Rome
Maria Manuela RIGANO, University of Naples Federico II

Eleonora COMINELLI

,

CNR-IBBA Milan

CRISPR/Cas9-mediated editing of GmSULTR3;3 uncovers a new approach for regulating phytic acid accumulation in soybean

Roméo Arago DOUGUÉ KENTSOP

,

CNR-IBBA Milan

From Nutritional Characterization to Active Packaging: An Integrated Evaluation of Vegetable Sprouts

Ambra Selene PARMAGNANI

,

University of Milan

Plant-derived nanocarriers for next-generation pest control and crop protection

Paolo PESARESI

,

University of Milan

Optimizing Canopy Photosynthesis in Barley: Identifying Optimal Allelic Variants within the BEST-CROP Project

Gerardo PUOPOLO

,

University of Trento

Heat-stable bacterial metabolites for sustainable crop protection: a strategy to enhance food security through reduced pesticide use.

Gianpiero VIGANI

,

University of Turin

Climate-Driven Changes in Mineral Nutrition: Implications for Sustainable Nutrition and Grain Quality in Durum Wheat

Sabrina SARROCCO

,

University of Pisa

Trichoderma gamsii T6085 as a biocontrol agent against Fusarium head blight of wheat: from modes of action to field performance

MS6: Health and disease

Chairs: Susanna AMBROSIO, University of Naples Federico II
Manuel GENTILUOMO, University of Pisa

Paola CAMPOMENOSI

,

University of Insubria

PRODH shapes tumor cell behavior and macrophage recruitment in lung adenocarcinoma models

Sonia CONI

,

Sapienza University of Rome

A zinc finger–NFATc3–MYC module links intestinal microbiota to colorectal tumorigenesis

Veronica DE GIORGIS

,

University of Piemonte Orientale

Proteomics-guided drug repurposing identifies novel therapeutic candidates in soft-tissue sarcoma

Laura GIANNOTTI

,

University of Salento

Cannabidiol in brain cancer treatment: modulation of NRF2 pathways and autophagy

Rida HAIDER

,

University of Palermo

A human In Vitro gut–brain axis model for genetic and functional evaluation of psychobiotics

Ludovica LOSPINOSO SEVERINI

,

Sapienza University of Rome

Discovery of a new selective ERAP1 inhibitor for Hedgehog-dependent cancer treatment

Michele MENDITTO

,

University of Palermo

Targeting TP53 nonsense mutations by Translational Readthrough: functional rescue of p53 and enhanced chemotherapy sensitivity

19.00 – 21.00

POSTER PRESENTATION

P1
P2
P3

P1: Enviromental, evolutionary and developmental biology

Chairs: Fabrizio ARANITI, University of Milan
Vittoria BRAMBILLA, University of Milan

Giulia Ave BONO

,

University of Milan

Rice florigenic proteins determine inflorescence architecture and flower fertility

Carla-Marie BRUNET

,

University of Parma

Genomic evidence for reduced close-kin reproduction in captive baboons

Maria Giuseppina CAMPANILE

,

University of Campania Luigi Vanvitelli

Insight into the amino acid sequence of canihuin, a type-1 ribosome inactivating protein from Chenopodium pallidicaule Aellen seeds

Sara CIMINI

,

Campus Bio-Medico University Rome

miR167 and miR530 define conserved and cultivar-specific miRNA networks to salt stress in temperate japonica rice

Corinne DAMIANI

,

University of Palermo

Native endophytic microbial consortia enhance grapevine resilience to drought and heat stress

Giorgia FABBRINI

,

University of Milan

Plant stress in a new light: novel fluorescent indicators to resolve mitochondrial calcium signatures in vivo

Nicolaj JERAN

,

University of Milan

Forever YounGreen: dissecting the staygreen phenotype to enhance barley yield and resilience

Thais HUARANCCA REYES

,

Univeristy of Pisa

Screening of wetland species for future multispecies remediation systems

Simone LANDI

,

University of Naples Federico II

Oxidative pentose phosphate pathway displays multi-layer post-translational regulation in photosynthetic organisms

Beatrice LANDONI

,

University of Milan

Subgenome-specific circadian growth regulation in tropical allopolyploid cotton under temperate conditions

Giacomo MERCURI

,

University of Parma

Gelada (Theropithecus gelada) genomic diversity sheds light on the biogeography of an endemic species of the ethiopian highlands

Erica MICA

,

Università Piemonte Orientale

Genome-wide association mapping of arsenic uptake and transport in rice using germanium oxide phenotyping

Ginevra Marie Eloise PEPPI

,

University of Bologna

Bridging mechanistic and physiological roles of Arabidopsis AKR4C subfamily in nitric oxide signaling and nitrosoglutathione catabolism

Paola PUNZO

,

IBBR-CNR, Portici

The splicing factor DRT111 regulates secondary dormancy induction in Arabidopsis thaliana

Camilla SANGIOVANNI

,

Tor Vergata University of Rome

Population structure and signatures of domestic introgression in Italian wild boar: insights from STRs and functional SNPs

P2: Genetics, epigenetics and chromosome biology

Chairs: Grazia Daniela RAFFA, University of Rome La Sapienza
Patrizia GUIDI, University of Pisa

Laura BAVAGNOLI

,

IGM-CNR, Pavia

A novel role for hsa-miR-1307-3p in R-loop homeostasis and genome stability.

Nicolò BEDOTTO

,

University of Pavia

Screening the DNA Damage Response pathway for seed quality hallmarks in Oryza sativa

Andrea BERNARDINI

,

University of Milan

Human-specific innovations in the basal transcription machinery: a novel TAF8 isoform increases TFIID assembly complexity in human cells

Mariarita BRANCACCIO

,

University of Naples Federico II

ZSCAN4–Telomerase Axis Activation Drives Genome Stability Programs in Preeclamptic Placenta

Giovanni DI FUSCO

,

University of Naples Federico II

Autophagy affects DNA damage response by modulating KAT5/TIP60 stability

Chiara FIORENTINO

,

University of Naples Federico II

DeXR: estimating X chromosome inactivation skewing from bulk RNA-seq data

Federica IRIS

,

University of Roma Tre

Oxidative stress as a modulator of DNA damage-induced innate immunity: insights into the cGAS-STING pathway

Giorgio MILAZZO

,

University of Bologna

Distinct CoREST complexes control tumor initiation and oncogenic transcription in neuroblastoma

Giorgio PERRELLA

,

University of Milan

Histone Deacetylase Complex 1 coordinates chromatin organization and transcriptional regulation to drive hypocotyl elongation in plants

Costantino PRECIPUO

,

University of Naples Federico II

Dissecting molecular and epigenetic alterations in Preeclampsia through complementary in vitro and ex vivo models

P3: Genomics, proteomics and systems biology

Chairs: Luigi LUCINI, Catholic University of the Sacred Heart, Piacenza
Francesca SACCO, University of Rome Tor Vergata
Giovanni SCALA, University of Naples Federico II

Fabrizio ARANITI

,

University of Milan

Unveiling the Phytotoxic Mode of Action of Nootkatone in Arabidopsis thaliana: An Integrated Multi-Omics Approach

Lidia AVALLE

,

University of Piemonte Orientale

From co-expression to causality: defining functional hub genes in basal-like breast cancer networks

Eleonora DAVIDE

,

University of Insubria

Genotype-specific changes in protein and metabolite content in wheat spikelet under nutrient and water stress

Davide DE LUCA

,

IFC-CNR, Pisa

Functional characterization of MYC point mutations identified in diffuse large B-cell lymphoma

Eleonora DI VENERE

,

University of Naples Federico II

From centrosome to primary cilium: the emerging role of TRIM8

Giulio FERRERO

,

University of Turin

The cancer-related DSCAM-AS1 lncRNA evolved midway through primate evolution via Transposable Element acquisition.

Monica GALBUSERA

,

University of Milan

Uncovering the role of polyploid giant cancer cells in high-grade serous ovarian cancer: new treatment perspectives

Silvia GIANOGLIO

,

University of Turin

Insights into the biosynthesis of irregular monoterpenoids from a newly identified α-trans-necrodyl diphosphate synthase from Lavandula stoechas subsp. luisieri

Parinaz KHANJANPOOR

,

University of Insubria

Transcriptomic analysis of advanced adenoma and colorectal cancer showed a widespread dysregulation of LINE-chimeric noncoding transcripts

Giorgia MODENINI

,

University of Padua

Transposable elements may contribute to the expression profiles of genes involved in human neurodevelopmental processes

Sabela NIKOLLI

,

IRCCS National Cancer Institute Regina Elena, Rome

Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53/Dicer complex

Emilia PICCIRILLI

,

University of L’Aquila

In vivo pectin breakdown by inducible expression of a fungal polygalacturonase in Arabidopsis as a tool to study subcellular proteome remodelling upon cell wall damage

08.30 – 10.30

SYMPOSIUM 7: Timing and Causes of Life Course Epigenetic modifications

Chairs: Giuseppe PASSARINO, Univerisity of Calabria
Giada FRENZILLI, Univerisity of Pisa

Graziano MARTELLO

,

University of Padua

Role of metabolism in the establishment of epigenetic features at early life stages

Wolfang WAGNER

,

Aachen University Medical School

Life-long and aging related modifications of the epigenetic landscape

Fabio COPPEDÈ

,

University of Pisa

Epigenetic effects of emerging pollutants

Annamaria BUSCHINI

,

University of Parma

Industrial hemp as a model plant for the genotoxic and epigenotoxic evaluation of perfluoroalkyl and polyfluoroalkyl substances (PFAS)

10.30 – 11.00

Coffee Break

11.00 – 13.00

SYMPOSIUM 8: AI in precision medicine

Chairs: Giulia PIAGGIO, IRCCS National Cancer Institute Regina Elena
Enrico DE SMAELE, University of Rome La Sapienza

Alberto TRAVERSO

,

IRCCS San Raffaele Hospital

What will it take to bring AI into personalized medicine?

Francesca CORDERO

,

University of Turin

Integrative Multi-Layer Longitudinal Modeling of MRD Trajectories in Clinical Trials

Egidio D’ANGELO

,

University of Pavia

Multiscale modelling and Brain Digital Twins

Fariba TOHIDINEZHAD

,

Erasmus MC Rotterdam

The Landmarks of Multimodal Learning in Medicine

13.00 – 13.30

Best presentation and poster awards

13.30 – 14.00

Closing Remarks

Posters will be available in your personal My Fisv Area (Posters section), from 21 Sept. to 20 Oct.

P1 – Enviromental, evolutionary and developmental biology

P1.2

Alessia AMETRANO, IBBC CNR Naples
Simulated marine heatwaves reveal epigenetic regulation of the polymeric immunoglobulin receptor gene in Antarctic teleosts

P1.3

Emanuele BOSI, University of Genoa
The resistome of European coastal environments revealed by high-resolution targeted metagenomics in oysters

P1.4

Giulia Ave BONO, University of Milan
Rice florigenic proteins determine inflorescence architecture and flower fertility

P1.5

Carla-Marie BRUNET, University of Parma
Genomic evidence for reduced close-kin reproduction in captive baboons

P1.6

Maria Giuseppina CAMPANILE, University of Campania Luigi Vanvitelli
Insight into the amino acid sequence of canihuin, a type-1 ribosome inactivatingArabidopsis protein from Chenopodium pallidicaule Aellen seeds

P1.7

Maurizio CARNÀ, University of Turin
β-cyclocitral is not required for acclimation to excess light at 25 °C

P1.8

Sara CIMINI, Campus Bio-Medico University Rome
miR167 and miR530 define conserved and cultivar-specific miRNA networks to salt stress in temperate japonica rice

P1.9

Corinne DAMIANI, University of Palermo
Native endophytic microbial consortia enhance grapevine resilience to drought and heat stress

P1.10

Giorgia FABBRINI, University of Milan
Plant stress in a new light: novel fluorescent indicators to resolve mitochondrial calcium signatures in vivo

P1.11

Valerio FOSCHI, Roma Tre University
Modulation of thermospermine metabolism alters xylem architecture and drought resilience in Solanum lycopersicum plants

P1.12

Flavia GRECO, University of Turin
Space worms: adaptation to microgravity and low magnetic field strength

P1.13

Thais HUARANCCA REYES, Univeristy of Pisa
Screening of wetland species for future multispecies remediation systems

P1.14

Simone LANDI, University of Naples Federico II
Oxidative pentose phosphate pathway displays multi-layer post-translational regulation in photosynthetic organisms

P1.15

Beatrice LANDONI, University of Milan
Subgenome-specific circadian growth regulation in tropical allopolyploid cotton under temperate conditions

P1.16

Giacomo MERCURI, University of Parma
Gelada (Theropithecus gelada) genomic diversity sheds light on the biogeography of an endemic species of the ethiopian highlands

P1.17

Erica MICA, Università Piemonte Orientale
Genome-wide association mapping of arsenic uptake and transport in rice using germanium oxide phenotyping

P1.18

Ginevra Marie Eloise PEPPI, University of Bologna
Bridging mechanistic and physiological roles of Arabidopsis AKR4C subfamily in nitric oxide signaling and nitrosoglutathione catabolism

P1.19

Benedetta PIZZICONI, Campus Bio-Medico, University of Rome
Polystyrene nanoplastics uptake and genotype-dependent responses in durum wheat: from hydroponic to soil-grown systems

P1.20

Paola PUNZO, IBBR-CNR, Portici
The splicing factor DRT111 regulates secondary dormancy induction in Arabidopsis thaliana

P1.21

Camilla SANGIOVANNI, Tor Vergata University of Rome
Population structure and signatures of domestic introgression in Italian wild boar: insights from STRs and functional SNPs

P1.23

Ruihan SHEN, University of Turin
KAI2 receptors shape the response to nitrogen limitation and nitrogen use efficiency in tomato

P1.24

Emanuele CAPRA, IBBA-CNR Lodi
PFNA exposure disrupts sperm function and reprograms the epigenome in male rats

P1.25

Nicolaj ERAN, University of Milan
Forever YounGreen: dissecting the staygreen phenotype to enhance barley yield and resilience

P2 – Genetics, epigenetics and chromosome biology

P2.1

Anna Maria Giuseppina POMA, University of L’Aquila
Effects of Polystyrene and Polyethylene Nanoparticles in Human Colorectal Cancer Cells

P2.2

Laura BAVAGNOLI, IGM-CNR Pavia
A novel role for hsa-miR-1307-3p in R-loop homeostasis and genome stability.

P2.3

Nicolò BEDOTTO, University of Pavia
Screening the DNA Damage Response pathway for seed quality hallmarks in Oryza sativa

P2.4

Andrea BERNARDINI, University of Milan
Human-specific innovations in the basal transcription machinery: a novel TAF8 isoform increases TFIID assembly complexity in human cells

P2.5

Vittoria BRAMBILLA, University of Milan
Stem growth in rice is controlled by chromatin remodelling that promotes cell division at the intercalary meristem

P2.6

Mariarita BRANCACCIO, University of Naples Federico II
ZSCAN4–Telomerase Axis Activation Drives Genome Stability Programs in Preeclamptic Placenta

P2.8

Erika CASARI, University of Milano Bicocca
Activation of MRX endonuclease by the Sae2 C-terminus: functional and molecular insights

P2.9

Elisa CIULLA, University of Palermo
DNA G-quadruplexes and nonsense mutations as dual targets for small-molecule-based cancer therapy

P2.10

Elvira CONIGLIO, University of Catania
Cell type-dependent activation of the NRF2-HMOX1 pathway following UVA and UVB irradiation

P2.11

Claudia COSTANZA, University of Palermo
Disruption of the LINC complex compromises DNMT1 dynamics

P2.12

Francesca SPARVOLI, IBBA-CNR
Optimized Whole-Genome Sequencing enables genome-wide mutation discovery in a new EMS-based common bean TILLING platform

P2.13

Giovanni DI FUSCO, University of Naples Federico II
Autophagy affects DNA damage response by modulating KAT5/TIP60 stability

P2.14

Chiara FIORENTINO, University of Naples Federico II
DeXR: estimating X chromosome inactivation skewing from bulk RNA-seq data

P2.15

Marco GNUGNOLI, University of Milano-Bicocca
Sae2 integrates CDK and checkpoint phosphorylation to coordinate MRX cleavage with checkpoint attenuation

P2.16

Martina GRECO, CIBIO University of Trento
The intranuclear protein quality control pathway sequesters excess histone H3 variant Cse4 to prevent chromosomal instability in budding yeast

P2.17

Federica IRIS, University of Roma Tre
Oxidative stress as a modulator of DNA damage-induced innate immunity: insights into the cGAS-STING pathway

P2.18

Sefora MARINO, University of Palermo
Rescuing REP1, RP1 and RPGR expression in Inherited Retinal Diseases (IRDs) models by translational readthrough approach

P2.19

Giannicola MAROTTA, University of Naples Federico II
8-oxodG as a driver of transcription and genome architecture

P2.20

Giorgio MILAZZO, University of Bologna
Distinct CoREST complexes control tumor initiation and oncogenic transcription in neuroblastoma

P2.21

Patrizia GUIDI, University of Pisa
Anti-genotoxic activity of Posidonia oceanica leaf extract in human intestinal Caco-2 cells: implications for human health

P2.22

Giorgio PERRELLA, University of Milan
Histone Deacetylase Complex 1 coordinates chromatin organization and transcriptional regulation to drive hypocotyl elongation in plants

P2.23

Anna PISCONE, University of Naples Federico II
XRCC1 deficiency promotes telomeric chromatin leakage, inflammatory signalling and senescence

P2.24

Costantino PRECIPUO, University of Naples Federico II
Dissecting molecular and epigenetic alterations in Preeclampsia through complementary in vitro and ex vivo models

P2.25

Erica ROSSI, University Roma Tre
Telomerase reverse transcriptase as a modulator of mitochondrial DNA and mitophagy

P2.26

Martina SANTULLI, University of Bologna
YEATS2 defines an E2F3-associated function of the ATAC core complex

P2.27

Esi TACI, University of Milan
Exploring the link between cellular senescence and neurodegeneration using iDISCO on brain organoids

P2.28

Giada FRENZILLI, University of Pisa
Genotoxicity biomarkers as potential predictors of very-long-term COVID-19 clinical sympthoms.

P2.29

Marco BERNASCONI, University of Milan
Transcription controls chromatin-nuclear lamina contacts through distinct Lamin A and LBR tethering mechanisms

P3 – Genomics, proteomics and systems biology

P3.1

Federica AMORUSO, University of Milano
Integrated CHARGE syndrome models reveal epigenetic modulators of reproductive phenotypes

P3.2

Fabrizio ARANITI, University of Milan
Unveiling the Phytotoxic Mode of Action of Nootkatone in Arabidopsis thaliana: An Integrated Multi-Omics Approach

P3.3

Lidia AVALLE, University of Piemonte Orientale
From co-expression to causality: defining functional hub genes in basal-like breast cancer networks

P3.4

Alessia CANEVOTTI, SEMM European School of Molecular Medicine, Milan
An integrative evidence framework and interactive resource for annotating the human pre-miRNA repertoire

P3.5

Eleonora DAVIDE, University of Insubria
Genotype-specific changes in protein and metabolite content in wheat spikelet under nutrient and water stress

P3.6

Davide DE LUCA, CNR Pisa
Functional characterization of MYC point mutations identified in diffuse large B-cell lymphoma

P3.7

Eleonora DI VENERE, University of Naples Federico II
From centrosome to primary cilium: the emerging role of TRIM8

P3.8

Guido DOMINGO, University of Insubria
Small peptides, big defense: chloroplast non-conventional peptides as novel regulators of thermal stress

P3.9

Giulio FERRERO, University of Turin
The cancer-related DSCAM-AS1 lncRNA evolved midway through primate evolution via Transposable Element acquisition.

P3.10

Margherita FERRETTI, IRCCS National Cancer Institute Regina Elena Rome
Spontaneous miscarriage reveals CD47-SIRPa axis as a targetable immune checkpoint in endometrial cancer

P3.11

Monica GALBUSERA, University of Milan
Uncovering the role of polyploid giant cancer cells in high-grade serous ovarian cancer: new treatment perspectives

P3.12

Silvia GIANOGLIO, University of Turin
Insights into the biosynthesis of irregular monoterpenoids from a newly identified α-trans-necrodyl diphosphate synthase from Lavandula stoechas subsp. luisieri

P3.13

Parinaz KHANJANPOOR, University of Insubria
Transcriptomic analysis of advanced adenoma and colorectal cancer showed a widespread dysregulation of LINE-chimeric noncoding transcripts

P3.14

Sophia LUCHE, University of Parma
Functional dynamics: metabolomic exploration of perennial wheat roots and their interacting microbial ecosystem

P3.15

Marcello MANFREDI, University of Piemonte Orientale
Unraveling CSF protein complex networks in neurodegenerative diseases

P3.16

Stefania MARTUCCIELLO, University of Salerno
Vegfr3 is required in the Tbx1 expression domain for cardiac outflow tract development.

P3.17

Giorgia MODENINI, University of Padova
Transposable elements may contribute to the expression profiles of genes involved in human neurodevelopmental processes

P3.18

Sabela NIKOLLI, IRCCS National Cancer Institute Regina Elena, Rome
Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53/Dicer complex

P3.19

Emanuela PEDRAZZINI, IBBA-CNR Milan
Lysine deserts in seed storage protein evolution

P3.20

Davide PEZZINI, University of Pavia
Multi-omics approach to investigate the impact of seed coat pigmentation on Trifolium alexandrinum germination

P3.21

Emilia PICCIRILLI, University of L’Aquila
In vivo pectin breakdown by inducible expression of a fungal polygalacturonase in Arabidopsis as a tool to study subcellular proteome remodelling upon cell wall damage

P3.22

Shraddha SHRIDHAR GAONKAR, University of Pavia
Metabolomic and ionomic changes mediated by antioxidant compounds in Populus nigra seeds

P4 – Current trends in biotechnology

P4.1

Germán Darío AHUMADA, Sant’Anna School of Advanced Studies, Pisa
Arabidopsis in vitro pipeline identified rice endophytic bacteria that promotes growth after submergence.

P4.2

Nicolò ALBANESE, University of Sannio
Engineering and characterization of third-generation CAR-macrophages for solid tumor immunotherapy

P4.3

Francesca AMODEO, University of Turin
Overcoming the silencing of doxycycline-inducible promoters in hiPSC-derived cardiomyocytes

P4.4

Giulia ANDERLUZZI, University of Milan
The effect of cationic polymer on the structure and pDNA transfection efficiency of lipopolyplexes

P4.5

Giacomo BIRRO, University of Verona
Primed for stress: loss of Aucsia2 improves salt resilience in tomato

P4.6

Michela BRUSCHI, University of Urbino Carlo Bo
Thiol-based compound hinders Pseudomonas aeruginosa pyocyanin redox cycling and dampens LPS-driven acute pulmonary inflammation

P4.7

Roberto CAFERRI, University of Verona
SPECTRAL RE-DESIGN OF LHCB PROTEINS FOR ENGINEERING PHOTOSYNTHETIC LIGHT USE EFFICIENCY

P4.8

Simona COMPARATO, Istituto Nazionale Oncologico Candiolo
Exploring the expression pattern of LINE-1–derived chimeric transcript of MET (L1-MET) across different tumor types

P4.9

Pasquale CREANZA, University of Urbino Carlo Bo
Development of a novel eco-friendly bioplastic from engineered phaseolin protein

P4.10

Marco DAINELLI, University of Florence
Constitutive metabolic adjustments underlying thallium hyperaccumulation in Silene latifolia

P4.11

Antimo DI MARO, University of Campania Luigi Vanvitelli
Celosin, a novel type-1 ribosome inactivating protein isolated from Celosia argentea L. seeds, demonstrates significant antiviral activity against coronaviruses in vitro

P4.12

Giulia BARBIERI, University of Pavia
Unlocking high-yield extracellular protease production in Bacillus subtilis by targeting the nutrient-responsive interplay between CodY and the stringent response

P4.13

Francesca GIANNESE, Human Technopole, Milan
The National Facility for Genomics of Human Technopole: Supporting Population Genomics Research and Technology Development in Italy

P4.14

Maria Raffaella BALESTRINI, CNR
Dissection of genotype-dependent grapevine responses to arbuscular mycorrhizal symbiosis

P4.15

Rita LOTRECCHIANO, University of Sannio
Extremely low- frequency electromagnetic stimulation as a non-invasive tool for modulating bacterial biofilms

P4.16

Elisa MARICCHIOLO, University of Urbino Carlo Bo
A new biotechnological platform for controlled anthocyanin biosynthesis via Sn overexpression in carrot callus cultures

P4.17

Mariagrazia MARTINI, University of Sannio
Effects of Extremely Low-Frequency Electromagnetic Fields on Wnt-Mediated Cardiac Differentiation of Human Induced Pluripotent Stem Cells

P4.18

Giovanni MESSINA, Link Campus University, Rome
Setting up of an in vitro model to investigate the effects on cell metabolism induced by the photobiomodulation protocols used for plantar fasciopathy

P4.19

Pietro ROVERSI, CNR-IBBA Milan
Structural Basis of ERAD-L Commitment by an EDEM:PDI Checkpoint Complex

P4.20

Maria SCRASCIA, University of Bari Aldo Moro
Polyurethane degrading bacteria isolates from plastic landfill: in vitro assays on solid and liquid media

P4.21

Suleman Khan ZADRAN, University of Bologna
A theranostic M13 phage nanoplatform for systematic CD276 targeting in neuroblastoma

P5 – Food and sustainable nutrition

P5.1

Emma BERTOLE’, University of Milan
Set up method for assessing the amount and activity of wheat germ agglutinin lectin

P5.2

Lorenzo BRUSETTI, Free University of Bolzano
Irrigation water quality drives antimicrobial resistance co-selection along the Adige Valley: preliminary findings from the AppleHealth project

P5.3

Beatrice CHIAVACCI, University of Florence
Crops that inherit their stress memories: Cicer arietinum against salt stress

P5.4

Eleonora COMINELLI, CNR-IBBA Milan
CRISPR/Cas9-mediated editing of GmSULTR3;3 uncovers a new approach for regulating phytic acid accumulation in soybean

P5.5

Elena DE AMICIS, University of L’Aquila
Microalgal bioactive compounds as natural elicitors for sustainable crop protection

P5.6

Noemi DI VITA, University of Padova
Proof of concept for RNAi-based weed control in Solanum nigrum

P5.7

Ridwan DIAGUNA, University of Pavia
Screening for heat stress tolerance in tomato: Impact on seed repair response

P5.8

Roméo Arago DOUGUÉ KENTSOP, CNR-IBBA Milan
From Nutritional Characterization to Active Packaging: An Integrated Evaluation of Vegetable Sprouts

P5.9

Alessandra MARINELLI, University of Milan
Anthocyanins as a possible strategy to protect against mycotoxin toxicity

P5.10

Andrea PAGANO, University of Pavia
Synergies in seed quality research to enhance stress tolerance in model and orphan legumes

P5.11

Ambra Selene PARMAGNANI, University of Milan
Plant-derived nanocarriers for next-generation pest control and crop protection

P5.12

Paolo PESARESI, University of Milan
Optimizing Canopy Photosynthesis in Barley: Identifying Optimal Allelic Variants within the BEST-CROP Project

P5.13

Gerardo PUOPOLO, University of Trento
Heat-stable bacterial metabolites for sustainable crop protection: a strategy to enhance food security through reduced pesticide use.

P5.14

Gianpiero VIGANI, University of Turin
Climate-Driven Changes in Mineral Nutrition: Implications for Sustainable Nutrition and Grain Quality in Durum Wheat

P5.15

Maria Manuela RIGANO, University of Naples Federico II
Effect of combined shade and drought stress on a S. pennellii introgression line.

P5.16

Sabrina SARROCCO, University of Pisa
Trichoderma gamsii T6085 as a biocontrol agent against Fusarium head blight of wheat: from modes of action to field performance

P5.17

Marta TOCCACELI, University of Milan
Purple corn anthocyanins encapsulated in zein nanoparticles and their role against inflammatory bowel diseases in vitro

P6 – Health and disease

P6.1

Giulia Luna BERGANTINO, University of Sannio
Selection of DNA aptamers targeting psoriasis-associated CARD14-mutant keratinocytes

P6.2

Stefano BIRESSI, University of Trento
Reduced fibrosis after in vivo inhibition of complement C1 in animal models of Duchenne Muscular Dystrophy

P6.3

Paola CAMPOMENOSI, University of Insubria
PRODH shapes tumor cell behavior and macrophage recruitment in lung adenocarcinoma models

P6.4

Ludovica CAPONE, University of Sannio
Disruption of macrophage CBM complex signaling impairs adipocyte metabolic homeostasis in vitro.

P6.5

Sonia CONI, Sapienza University of Rome
A zinc finger–NFATc3–MYC module links intestinal microbiota to colorectal tumorigenesis

P6.6

Maria Rosaria COSCIA, National Research Council
Immune adaptations to acute and chronic hypobaric hypoxia: molecular insights from Antarctic and simulated environments

P6.7

Veronica DE GIORGIS, University of Piemonte Orientale
Proteomics-guided drug repurposing identifies novel therapeutic candidates in soft-tissue sarcoma

P6.8

Rosita DI PALMA, University of Naples Federico II
Targeting oxidative and ER stress to improve chemotherapy in lung cancer cell: the adjuvant role of olea europaea in lung cancer

P6.9

Chiara DONATI, University of Pavia
Novel Riluzole-derivative VA942 affects voltage-gated sodium and potassium currents expressed in SH-SY5Y-derived neurons

P6.10

Laura GIANNOTTI, University of Salento
Cannabidiol in brain cancer treatment: modulation of NRF2 pathways and autophagy

P6.11

Rida HAIDER, University of Palerrmo
A human In Vitro gut–brain axis model for genetic and functional evaluation of psychobiotics

P6.12

Ludovica LOSPINOSO SEVERINI, Sapienza University of Rome
Discovery of a new selective ERAP1 inhibitor for Hedgehog-dependent cancer treatment

P6.13

Federico MANAI, University of Pavia
TET2 dysregulation identifies genomically unstable and prognostically relevant subgroups in high-grade serous ovarian carcinoma

P6.14

Nicole MARCATI, University of Parma
Parallel Evolution of a GLP1R Residue in Mammals and Humans Reveals a Pharmacogenomic Determinant of GLP-1 Receptor Agonist Response

P6.15

Valentina MARGARITA, University of Sassari
Sex-based differences in prenatal innate immunity: divergent foetal responses to Mycoplasma hominis infection between males and females

P6.16

Michele MENDITTO, University of Palermo
Targeting TP53 nonsense mutations by Translational Readthrough: functional rescue of p53 and enhanced chemotherapy sensitivity

P6.17

Francesco ACQUATI, University of Insubria
Role of the human RNASET2 gene in the pathogenesis of Aicardi-Goutières syndrome.

P6.18

Shirin NAVACCI, Sapienza University of Rome
AMBRA1 regulates Sonic Hedgehog signaling during cerebellar development and promotes SHH-medulloblastoma

P6.19

Roberto OLEARI, University of Milan
Connecting craniofacial malformations with neural crest splicing defects by defining the role of nuclear cyclophilin NKTR

P6.20

Zeudi PETRONE, University of Naples Federico II
Modelling diabetic corneal injury in ovo: a rapid platform for testing bioactive ophthalmic formulations

P6.21

Valentina POZZI, Polytechnic University of Marche
The role of catechol-o-methyltransferase dysregulation in human urothelial carcinoma development

P6.22

Davide SARTINI, Marche Polytechnic University
Therapeutic potential of paraoxonase-2 enzyme in triple-negative breast cancer treatment

P6.23

Chiara SCAPOLI, University of Ferrara
Recurrent pregnancy loss and smoking share CTNNA2 rs4852592 locus effects through independent pathways

P6.24

Gabriele SALES, University of Padova
Self-supervised learning reveals mutation-specific morphological signatures in Gaucher disease fibroblasts